Project Implementation

(Leader: INCLIVA) Duration: M1-M48 

WP 1 assures progress and financial management of AIDA, communication between the partners and reporting. It contains communication and dissemination to external stakeholders, patients and society at large. This WP includes the following tasks: 

Task 1.1. General project management 

Task 1.2. Approve ethics and other relevant requirements, including data management plan 

Task 1.3. Coordinate CRF implementation at the different sites 

Task 1.4. Manage and monitor inclusivity and gender 

Task 1.5. Manage clinical studies 

(Leader: FIBHUP) Duration: M1-M48 

The main objectives of WP2 include to provide H. pylori patients’ baseline characteristics, diagnostics’ methods, bacterial resistance rates to the different treatments prescriptions, as well as treatment outcomes in the different contexts of the registry (geographic, specific populations, specific interventions, etc.) in order to contribute to the development of the state-of-the-art App, the AI-powered expert system, AIDA. WP2 includes the following tasks: 

Task 2.1. Prepare and harmonise the data registry 

Task 2.2. Systematic and periodical data analysis and synthesis of the Information 

Task 2.3. Data set preparation 

Task 2.4. Create a validation cohort to test the AI-driven best practices

(Leader: IPO Porto) Duration: M1-M48 

The main aims of WP3 are to develop and validate diagnostic algorithms for detecting and characterising high-risk lesions in gastric mucosa, both for endoscopy recordings (images/videos) and pathology (digital whole slide images – WSI) using derivation and validation cohort. WP3 includes the following tasks: 

Task 3.1. Define data requirements and harmonisation in endoscopy and pathology 

Task 3.2. Create the technological structure to pool endoscopy and pathology data 

Task 3.3. Collect and validation of endoscopy data 

Task 3.4. Build the AI-based endoscopy model for the target macroscopic lesions 

Task 3.5. Collect and validate pathology data 

Task 3.6. Build the AI-based pathology model for the microscopic target lesions 

(Leader: INCLIVA) Duration: M6-M48 

WP4 aims to characterise patients diagnosed with gastrointestinal metaplasia (GIM) through cases-control sets using a multi-omics strategy, including the immune, molecular, and microbiome profiling to provide knowledge on the biological features related with gastric chronic inflammation; and to identify biological characteristics that could improve precision diagnosis for the risk groups of patients diagnosed with GIM beyond the pathological characteristics. WP4 includes the following tasks: 

Task 4.1. Develop data sets for biomarker characterisation 

Task 4.2. Immune characterisation of patients with gastrointestinal metaplasia (GIM) 

Task 4.3. Microbiome characterisation 

Task 4.4. H. pylori subtypes characterisation 

Task 4.5. Molecular characterisation of patients with GIM 

(Leader: Imperial) Duration: M4-M48 

WP5 develops explainable and network-driven AI workflows for personalised risk stratification, biomarker discovery and H. pylori eradication therapy selection using multi-source clinical, imaging and omics data. WP5 includes the following tasks: 

Task 5.1. Create AI reinforcement learning H. pylori management 

Task 5.2. Design and validate explainable AI for endoscopy and pathology data 

Task 5.3. Design and validate graph neural networks for multi-omics 

Task 5.4. Develop data/model integrators 

(Leader: Stratejai) Duration: M1-M48 

The objective of WP6 is to develop a data governance structure that enables access to data to all stakeholders while minimising negative impact. This includes designing a shared data governance model that increases trust and demonstrates trustworthiness with how data is collected, shared, and used. WP6 includes the following tasks: 

Task 6.1. Establish the foundation and define governance 

Task 6.2. Design architecture 

Task 6.3. Data ingestion pipeline—Back end 

Task 6.4. Front end (dashboards and analytics) 

Task 6.5. Develop the technological component of the use cases 

Task 6.6. Harmonise with European Data Spaces, FAIR and ALTAI principles 

(Leader: DiCE) Duration: M1-M48 

The main goal of WP7 is to disseminate the results of the AIDA project through a diverse range of communications tools (AIDA app and dashboards, website, social media channels, educational programmes), aimed at the expert audiences (e.g., clinicians and researchers), patients and citizens at risk of developing gastric cancer, and the general public. It also targets external stakeholders in the field of gastric inflammation management and prevention in order to demonstrate the feasibility of the foundation. WP7 includes the following tasks: 

Task 7.1. Conduct impact assessment and cost-benefit analysis with stakeholders 

Task 7.2. Run awareness campaigns and educational programmes 

Task 7.3. Validate business cases for economic sustainability 

(Leader: INCLIVA) Duration: M1-M48 

The objective of WP8 is to ensure compliance with the ‘ethics requirements’ set out in this work package. This work package sets out the ‘ethics requirements’ that the project must comply with.